Andrographolide, Apoptosis Inducer
Size
500 mgCatalog no#
SIH-220-500MGPrice
211 EURNet weight (g)
0.5
Soluble in
DMSO
Total weight (kg)
0.25
Purity pourcentage
>98%
Country of production
Canada
Storage recommendations
-20ºC
PubChem number
5318517
Product type
Inducer
Chemical formula
C20H30O5
Stock availabilitIn Stock
In Stock
Origin
Synthetic
CAS number
5508-58-7
Release date
8-Apr-2011
Tested applications
To be tested
Tested reactivity
To be tested
Molecular weight
350,45 g/mol
Warning information
Non-hazardous
Product category
Small Molecules
Shipping recommendations
Shipped Ambient
PubMed number
Refer to PubMed
Physical appearance
Off-white Solid
Primary research fields
Cancer, Apoptosis
Description
Apoptosis Inducer
Additional description
This 1 is suited for programmed cell-death studies.
Other name
(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone
Bibliography
1. Chakravarti R.N., Chakravarti D. (1951) Ind. Med Gaz. 86(3): 96-7. 2. Tsai H.R., et al. (2004) Eur J Pharmacol. 498: 45-52. 3. Rajagopal S., et al. (2003) J Exp. Ther. Oncol. 3: 147-158.
Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Scientific context
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement (2, 3).
Representative figure legend
Chemical structure of Andrographolide (SIH-220), a Induces mitochondrial -mediated apoptosis in lymphoma cells. CAS #: 5508-58-7. Molecular Formula: C20H30O5. Molecular Weight: 350.45 g/mol. Chemical structure of Andrographolide, a Induces mitochondrial -mediated apoptosis in lymphoma cells (SIH-220). CAS # 5508-58-7. Molecular Formula: C20H30O5.