Valinomycin, Apoptosis Inducer
Size
50 mgCatalog no#
SIH-230-50MGPrice
216 EURPurity pourcentage
>98%
Net weight (g)
0.05
Total weight (kg)
0.25
PubChem number
5649
Country of production
Canada
Storage recommendations
-20ÂșC
Product type
Inducer
Stock availabilitIn Stock
In Stock
Origin
Synthetic
CAS number
2001-95-8
Physical appearance
White Solid
Release date
16-May-2011
Chemical formula
C54H90N6O18
Tested reactivity
To be tested
Tested applications
To be tested
Molecular weight
1111,32 g/mol
Warning information
Non-hazardous
Product category
Small Molecules
Shipping recommendations
Shipped Ambient
PubMed number
Refer to PubMed
Primary research fields
Cancer, Apoptosis
Description
Apoptosis Inducer
Soluble in
Soluble to 25 mM in DMSO and 25 mM in ethanol.
Additional description
This 1 is suited for programmed cell-death studies.
Bibliography
1. Lars R., Jenkins A.T.A. (2007) Bioelectrochem. 70(2): 387-393. 2. Cammann K. (1985) Top Curr Chem. 128: 219-258.
Other name
(3R,6R,9S,12S,15R,18R,21S,24S,27R,30R,33S,36S)-3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29, 32,35-dodecone
Representative figure legend
Chemical structure of Valinomycin (SIH-230), a Induces loss of mitochondrial membrane potential. CAS #: 2001-95-8. Molecular Formula: C54H90N6O18. Molecular Weight: 1111.32 g/mol. Chemical structure of Valinomycin, a Induces loss of mitochondrial membrane potential (SIH-230). CAS # 2001-95-8. Molecular Formula: C54H90N6O18.
Scientific context
Valinomycin is a dodecadepsipeptide, and a member of a group of natural neutral ionophores. It is highly selective for potassium ions within the cell membrane (1). It functions as a potassium-specific transporter and facilitates the movement of potassium ions through lipid membranes down an electrochemical potential gradient (2).
Safety information
Classification: Very Toxic. May be fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed R68 - Possible risk of irreversible effects Hazard Phrases: H300-H310 Precautionary Phrases: P264-P280-P302 + P350-P310