Piperlongumine, Apoptosis Inducer

Size

20 mg

Catalog no#

SIH-156-20MG

Price

156 EUR

Purity pourcentage

>98%

Net weight (g)

0.02

Total weight (kg)

0.25

Country of production

Canada

Storage recommendations

-20ÂșC

PubChem number

637858

Product type

Inducer

Stock availabilitIn Stock

In Stock

Chemical formula

C17H19NO5

Origin

Synthetic

CAS number

20069-09-4

Physical appearance

Cream Solid

Release date

26-Aug-2011

Molecular weight

317,3 g/mol

Tested reactivity

To be tested

Tested applications

To be tested

Warning information

Non-hazardous

Product category

Small Molecules

Shipping recommendations

Shipped Ambient

PubMed number

Refer to PubMed

Description

Apoptosis Inducer

Primary research fields

Cancer, Oxidative Stress

Soluble in

Soluble in 25 mg/ml DMSO

Additional description

This 1 is suited for programmed cell-death studies.

Other name

1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone

Bibliography

1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199. 2. Raj L., et al. (2011) Nature. 475(7355): 231.

Safety information

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302

Representative figure legend

Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol. Chemical structure of Piperlongumine, a Apoptosis inducer in oxidative stressed cells (SIH-156). CAS # 20069-09-4. Molecular Formula: C17H19NO5.

Scientific context

Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).