Piperlongumine, Apoptosis Inducer
Size
20 mgCatalog no#
SIH-156-20MGPrice
156 EURPurity pourcentage
>98%
Net weight (g)
0.02
Total weight (kg)
0.25
Country of production
Canada
Storage recommendations
-20ÂșC
PubChem number
637858
Product type
Inducer
Stock availabilitIn Stock
In Stock
Chemical formula
C17H19NO5
Origin
Synthetic
CAS number
20069-09-4
Physical appearance
Cream Solid
Release date
26-Aug-2011
Molecular weight
317,3 g/mol
Tested reactivity
To be tested
Tested applications
To be tested
Warning information
Non-hazardous
Product category
Small Molecules
Shipping recommendations
Shipped Ambient
PubMed number
Refer to PubMed
Description
Apoptosis Inducer
Primary research fields
Cancer, Oxidative Stress
Soluble in
Soluble in 25 mg/ml DMSO
Additional description
This 1 is suited for programmed cell-death studies.
Other name
1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone
Bibliography
1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199. 2. Raj L., et al. (2011) Nature. 475(7355): 231.
Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
Representative figure legend
Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol. Chemical structure of Piperlongumine, a Apoptosis inducer in oxidative stressed cells (SIH-156). CAS # 20069-09-4. Molecular Formula: C17H19NO5.
Scientific context
Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).